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Related Experiment Videos

Extreme thrombocytosis associated with malignancy

S C Spigel, L R Mooney

    Cancer
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Extreme thrombocytosis, a rare platelet elevation, resolved after lung cancer radiotherapy. This case highlights the crucial link between unexplained high platelet counts and potential malignancy.

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    Area of Science:

    • Oncology
    • Hematology

    Background:

    • Thrombocytosis, or elevated platelet count, can be reactive or clonal.
    • Extreme thrombocytosis is uncommon, particularly in association with solid tumors.

    Observation:

    • A patient presented with a platelet count of 6,000,000/mm3.
    • This extreme thrombocytosis was associated with adenocarcinoma of the lung.

    Findings:

    • The platelet count normalized after definitive radiotherapy of the lung adenocarcinoma.
    • No thrombohemorrhagic complications were observed despite the severe thrombocytosis.

    Implications:

    • Unexplained thrombocytosis, especially when extreme, warrants thorough investigation for underlying malignancy.
    • This case suggests a paraneoplastic phenomenon where tumor treatment can resolve thrombocytosis.