Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation of ventricular refractoriness in man by the extra stimulus method

B Olsson, L Brorson, R Harper

    Cardiovascular Research
    |January 1, 1977
    PubMed
    Summary

    The effective right ventricular refractory (EVRP) period shortens with faster heart rates. This study shows the EVRP technique is reliable for assessing drug effects on individual patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anthropometric, Body Composition, and Nutritional Indicators with and without Nutritional Intervention during Nitisinone Therapy in Alkaptonuria.

    Nutrients·2024
    Same author

    Joint replacement risk is markedly increased in alkaptonuria (AKU) in those with prior arthroplasty.

    Molecular genetics and metabolism reports·2024
    Same author

    Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria.

    Scientific reports·2022
    Same author

    Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.

    Molecular genetics and metabolism·2022
    Same author

    Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria.

    Molecular genetics and metabolism reports·2022
    Same author

    MSX1 is differentially expressed in the deepest impacted maxillary third molars.

    The British journal of oral & maxillofacial surgery·2020

    Area of Science:

    • Electrophysiology
    • Cardiology

    Background:

    • The effective right ventricular refractory (EVRP) period is a critical electrophysiological parameter.
    • Understanding EVRP variability is essential for cardiac pacing and antiarrhythmic drug efficacy.

    Purpose of the Study:

    • To estimate the effective right ventricular refractory (EVRP) period in patients.
    • To assess the reliability of the EVRP estimation technique for drug efficacy studies.

    Main Methods:

    • Utilized the extra stimulus technique to measure EVRP in 24 patients.
    • Pacing was performed from the right ventricle at various basic pacing intervals (400, 500, 600, 800 ms).

    Main Results:

    • EVRP significantly decreased as the basic pacing rate increased across all patients.

    Related Experiment Videos

  • Wide inter-patient variability in EVRP was observed at identical pacing rates.
  • Intra-patient EVRP measurements remained stable over 15-30 minutes with consistent electrode position.

    • Conclusions:

    • The effective right ventricular refractory period is rate-dependent.
    • The EVRP estimation technique demonstrates intra-patient reliability, making it suitable for evaluating drug effects on refractory periods.