Related Experiment Video
Updated: Aug 7, 2026

Assessment of Ultrasonic Vocalizations During Drug Self-administration in Rats
Published on: July 22, 2010
[The frequency characteristics of the reaction to the intravenous self-administration of narcotics]
Abstract:
Rat experiments have shown that the histograms of intervals between the self-injections of narcotic analgesics (morphine, promedol, buprenorphine) and psychomotor stimulants (cocaine, amphetamine) were essentially different. The quantitative measures of these differences are presented as discrepancy coefficients in the interval distribution between self-injections. The computerized "real time" system for collecting and analyzing the experimental findings of intravenous self-injection was used in rats.
Related Concept Videos
Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Factors Affecting Drug Response: Overview
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Analgesia and Pain Management
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drug Accumulation During Multiple Dosing: Repetitive IV Injections

