[The efficacy of phenol antioxidants in vitro and in vivo]

The antioxidative activity of ionol, 2,2'methylene-bis(6-tert-butyl-4-methylphenol), 2,2-ethylenebis (6-tert-butyl-4-methylphenol), 2,2-propylenebis (6-tert-butyl-4-methylphenol, 2,2-butylenebis (6-tert-butyl-4-methylphenol) was studied in models and in albino rats with experimental hyperthyroidism. The most intensive extinguishing of induced chemiluminescence was found to be produced by 2,2-methylenebis (6-tert-butyl-4-methylphenol) and 2,2-ethylenebis (6-tert-butyl-4-methylphenol). These substances produced the most inhibitory effects on lipid peroxidation in the heart of hyperthyroidism animals.