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Congenital syphilitic skeletal manifestations in a premature infant revisited
Insights
Congenital syphilis rates are rising despite available treatments. This case highlights early congenital syphilis in a premature infant, emphasizing the risks of untreated maternal syphilis for neonatal outcomes.
Area of Science:
- Neonatology
- Infectious Diseases
- Obstetrics
Background:
- Congenital syphilis rates are increasing globally.
- Maternal syphilis, if untreated, poses significant risks to neonatal health.
- Approximately 1.5% of newborns in our center show reactive syphilis tests.
Abstract:
Increasing rates of congenital syphilis have been reported in recent years despite the availability of adequate therapy. In our perinatal-neonatal center, approximately 1.5% of newborns have reactive serologic tests for syphilis. Untreated or partly treated maternal syphilis can adversely affect neonatal outcome since the treponeme can cross the placenta at any time during pregnancy. As a result of hematogenous placental transmission, neonatal manifestations are usually systemic and similar to the secondary stage of syphilis, and include hepatosplenomegaly, jaundice, neurosyphilis, and skeletal changes. A case of early congenital syphilis in an extremely premature infant with primary skeletal involvement is presented.
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