Ferric sulfate hemostasis: effect on osseous wound healing. Left in situ for maximum exposure

Ferric sulfate solution is an accepted soft tissue hemostatic agent for use in dermatology and dentistry. This study was designed to test its effect on osseous healing when used during surgery to control osseous hemorrhage. Standardized osseous defects were created bilaterally in the naturally edentulous zone in rabbit mandibles. The control site was sutured immediately after clot formation in the defect. The contralateral experimental site received ferric sulfate application until complete hemostasis was achieved. The defect was filled with ferric sulfate solution to maximize any effect on healing and then closed with sutures. The experimental and control specimens were examined histologically after 18 and 46 days and scored for healing. Statistical analysis by Wilcoxon signed rank test showed significant adverse effects on osseous healing when ferric sulfate solution was left in situ.