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Related Experiment Videos

Linac-based small-field radiotherapy for brain tumors

K Tokuuye1, Y Akine, N Tokita

  • 1Department of Radiation Therapy, National Cancer Center Hospital, Tokyo, Japan.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|April 1, 1993
PubMed
Summary

This study introduces a simple, frameless radiotherapy system for brain tumors, offering fractionated treatment with good dose distribution and minimal errors. The approach proved effective and well-tolerated in patients previously untreatable by radiosurgery.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Neurosurgery

Background:

  • Investigating small-field radiotherapy as an alternative to stereotactic radiosurgery.
  • Utilizing a 6-MeV linear accelerator (linac) and a conventional head mold.
  • Aiming for a system that avoids additional devices and enables fractionated treatment.

Observation:

  • Dose distributions achieved are comparable to Gamma Unit stereotactic radiosurgery.
  • Overall patient positioning errors were consistently within 2 mm.
  • Seven patients with brain tumors, previously untreatable, underwent this fractionated radiotherapy.

Findings:

  • Total accumulated doses ranged from 70 to 108 Gy.
  • The treatment was well-tolerated, with no acute toxicity observed during 8-14 months follow-up.

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  • All patients remained disease-free within the treated volumes.

    • Implications:

    • This frameless, fractionated radiotherapy system is a simple, inexpensive, and effective option for small intracranial malignancies.
    • It expands treatment options for patients with brain tumors unsuitable for conventional radiosurgery.
    • Further follow-up is warranted, but preliminary results are promising for this novel approach.