Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transfusion therapy for severe anemia

S Jayabose1, O Tugal, R Ruddy

  • 1Division of Pediatric Hematology/Oncology, New York Medical College, Valhalla 10595.

The American Journal of Pediatric Hematology/Oncology
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prosthetic rehabilitation of maxillary lateral incisors agenesis using dental mini-implants: a multicenter 10-year follow-up.

Clinical oral investigations·2021
Same author

Sella turcica and craniofacial morphology in patients with palatally displaced canines: a retrospective study.

Folia morphologica·2019
Same author

Designing Trials of Disease Modifying Agents for Early and Preclinical Alzheimer's Disease Intervention: What Evidence is Meaningful to Patients, Providers, and Payers?

The journal of prevention of Alzheimer's disease·2018
Same author

Modification of growth, immunologic and feeding parameters in children with OSAS after adenotonsillectomy.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale·2018
Same author

Primary hyperoxaluria: Orthodontic management in a pediatric patient: A case report.

Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·2018
Same author

Elimination of micropollutants by activated carbon produced from fibers taken from wastewater screenings using hydrothermal carbonization.

Journal of environmental management·2018
Same journal

Transient abnormal myelopoiesis in Down's syndrome neonates.

The American journal of pediatric hematology/oncology·1994
Same journal

Secondary acute promyelocytic leukemia in a child treated with epipodophyllotoxins.

The American journal of pediatric hematology/oncology·1994
Same journal

Maternal malignancy involving the products of conception: a report of malignant melanoma and medulloblastoma.

The American journal of pediatric hematology/oncology·1994
Same journal

Sphenoid sinus involvement in neuroblastoma.

The American journal of pediatric hematology/oncology·1994
Same journal

Transient lupus anticoagulant associated with prothrombin deficiency: unusual cause of bleeding in a 5-year-old girl.

The American journal of pediatric hematology/oncology·1994
Same journal

Disseminated histoplasmosis: a cause of infection-associated hemophagocytic syndrome.

The American journal of pediatric hematology/oncology·1994
See all related articles

This study found that a continuous packed red blood cell (PRBC) transfusion regimen is safe and effective for children with severe anemia, improving hematocrit levels without causing heart failure.

Area of Science:

  • Pediatric Hematology
  • Transfusion Medicine

Background:

  • Severe anemia in children necessitates careful transfusion management.
  • Traditional transfusion methods may pose risks.

Purpose of the Study:

  • To evaluate the safety and efficacy of a novel continuous packed red blood cell (PRBC) transfusion regimen.
  • To assess the impact of this regimen on hematocrit levels and cardiac function in pediatric patients.

Main Methods:

  • A continuous infusion PRBC regimen at 2 cc/kg/h was administered to 22 children with severe anemia (hemoglobin < 5 g/dl).
  • Patients were monitored for clinical signs of heart failure during and after transfusion.
  • Hematocrit increase per unit of PRBC transfused was calculated.

Main Results:

Related Experiment Videos

  • No instances of cardiac failure or increased heart rate were observed.
  • A mean heart rate decrease of 28% was noted post-transfusion.
  • An average hematocrit increase of approximately 1.04% per cc/kg of PRBC was achieved in patients without sickle cell anemia.

Conclusions:

  • Continuous PRBC transfusion at 2 cc/kg/h is a safe and effective method for managing severe anemia in children.
  • This regimen leads to a predictable increase in hematocrit, approximately 1% per cc/kg of PRBC transfused.
  • The regimen is particularly effective for gradual onset anemia, excluding sickle cell anemia cases.