Related Experiment Video

Updated: May 12, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

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Published on: January 27, 2013

Trimethoprim-sulfamethoxazole induces reversible hyperkalemia

S Greenberg1, I W Reiser, S Y Chou

  • 1Brookdale Hospital Medical Center, Brooklyn, New York.

Annals of Internal Medicine
|August 15, 1993
PubMed
Summary

High-dose trimethoprim-sulfamethoxazole (Tmp-Smx) significantly increases serum potassium levels in HIV patients with Pneumocystis pneumonia. Close monitoring is crucial to prevent potentially life-threatening hyperkalemia during Tmp-Smx therapy.

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