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Related Experiment Videos

Fluoxetine and tics in an adolescent

G Eisenhauer1, D M Jermain

  • 1Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Temple.

The Annals of Pharmacotherapy
|June 1, 1993
PubMed
Summary

Fluoxetine, a selective serotonin reuptake inhibitor, may cause tics in adolescents. These extrapyramidal symptoms resolved after discontinuing fluoxetine treatment.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are commonly prescribed for depression.
  • Adverse effects of SSRIs can include neurological symptoms, though extrapyramidal symptoms are less common.

Observation:

  • A case study of an adolescent treated with fluoxetine for depression is presented.
  • The patient developed numerous tics after eight months of fluoxetine therapy.
  • Tics subsided six months after fluoxetine discontinuation.

Findings:

  • Fluoxetine treatment in an adolescent was associated with the development of severe extrapyramidal symptoms (tics).
  • This association has not been previously reported in adolescent populations.
  • The observed tics resolved upon cessation of fluoxetine, suggesting a causal link.

Implications:

  • This case suggests fluoxetine may be linked to extrapyramidal adverse reactions, even in adolescents.
  • Serotonin's modulation of dopaminergic neurons is a potential mechanism for these effects.
  • Clinicians should be aware of the potential for fluoxetine-induced tics in adolescent patients.

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