Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic multifocal osteomyelitis

A J Carr1, W G Cole, D M Roberton

  • 1Royal Children's Hospital, Melbourne, Victoria, Australia.

The Journal of Bone and Joint Surgery. British Volume
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Xanthomatous Giant Cell Renal Cell Carcinoma: Another Morphologic Form of TSC -associated Renal Cell Carcinoma.

The American journal of surgical pathology·2022
Same author

Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.

The Journal of allergy and clinical immunology·2021
Same author

Peri-operative administration of tranexamic acid in lower limb arthroplasty: a multicentre, prospective cohort study.

Anaesthesia·2020
Same author

The use of a patch to augment rotator cuff surgery - A survey of UK shoulder and elbow surgeons.

PloS one·2020
Same author

Optimizing the design of invasive placebo interventions in randomized controlled trials.

The British journal of surgery·2020
Same author

Wrist pain: a systematic review of prevalence and risk factors- what is the role of occupation and activity?

BMC musculoskeletal disorders·2019
Same journal

Comorbidities in Perthes' disease: a case control study using the General Practice Research database.

The Journal of bone and joint surgery. British volume·2012
Same journal

The treatment of complex tibial shaft fractures by the Ilizarov method.

The Journal of bone and joint surgery. British volume·2012
Same journal

Posterior spinal arthrodesis for adolescent idiopathic scoliosis using pedicle screw instrumentation: does a bilateral or unilateral screw technique affect surgical outcome?

The Journal of bone and joint surgery. British volume·2012
Same journal

Anterior deltoid deficiency in reverse total shoulder replacement: a biomechanical study with cadavers.

The Journal of bone and joint surgery. British volume·2012
Same journal

Long-term results of dorsal intercarpal ligament capsulodesis for the treatment of chronic scapholunate instability.

The Journal of bone and joint surgery. British volume·2012
Same journal

Medial patellofemoral ligament reconstruction for patellar instability in patients with hypermobility: a case control study.

The Journal of bone and joint surgery. British volume·2012
See all related articles

This study details 22 pediatric patients with osteomyelitis-like bone lesions and associated symptoms. Most patients experienced good long-term outcomes without significant developmental issues.

Area of Science:

  • Pediatric Rheumatology
  • Pediatric Orthopedics
  • Pediatric Infectious Diseases

Background:

  • Osteomyelitis is a bone infection often presenting with localized pain and inflammation.
  • Differentiating infectious osteomyelitis from other bone pathologies in children can be challenging.
  • Idiopathic bone lesions in pediatric populations require thorough investigation.

Purpose of the Study:

  • To describe the clinical presentation, diagnostic findings, and outcomes of pediatric patients with multifocal bone lesions.
  • To evaluate the efficacy of various treatment modalities for these bone lesions.
  • To assess the long-term prognosis and potential complications in affected children.

Main Methods:

  • Retrospective case series of 22 pediatric patients aged 4-14 years.

Related Experiment Videos

  • Clinical evaluation including symptom onset, duration, and associated conditions.
  • Radiological assessment (X-rays, radioisotope bone scans) and bone biopsies for histopathological analysis.
  • Review of treatment responses and long-term follow-up data.

    • Main Results:

    • Patients presented with gradual onset malaise and pain at multiple bone lesion sites, mimicking osteomyelitis.
    • Radiological findings were typical of osteomyelitis; bone scans detected clinically silent lesions.
    • Bone biopsies showed osteomyelitis changes in 17/20 patients, with only one positive microbiological culture.
    • Associated conditions included polyarthritis, palmoplantar pustulosis, and psoriasis.
    • Symptomatic relief achieved with anti-inflammatory agents and antibiotics; no primary immunodeficiency identified.
    • Mean bone lesion symptom duration was 2 years; joint symptoms lasted longer (mean 7 years).

    Conclusions:

    • The described condition presents radiologically as osteomyelitis but often lacks microbiological confirmation.
    • Anti-inflammatory agents appear beneficial, suggesting a non-infectious or post-infectious inflammatory component.
    • Long-term prognosis is generally favorable with minimal impact on bone growth or joint development.
    • Further research is needed to elucidate the underlying etiology of these multifocal bone lesions.