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The PIR-International databases

W C Barker1, D G George, H W Mewes

  • 1Protein Information Resource, National Biomedical Research Foundation, Georgetown University Medical Center.

Nucleic Acids Research
|July 1, 1993
PubMed
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PIR-International manages scientific databases, including the Protein Sequence Database, to support research on protein evolution and intersequence relationships through international cooperation. These valuable genomic and protein sequence resources are made widely accessible to the scientific community.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • PIR-International is a collaborative association of macromolecular sequence data centers.
  • It is renowned for the Protein Sequence Database, initiated by Margaret Dayhoff in the 1960s.
  • The database serves as a research tool for studying protein evolution and relationships.

Purpose of the Study:

  • To describe the architecture of the Protein Sequence Database.
  • To present other genomic and protein sequence databases maintained by PIR-International.
  • To outline mechanisms for database access and distribution.

Main Methods:

  • Utilizing sequence homology as a guiding principle for database organization.
  • Maintaining databases as scientific resources organized by biological concepts.

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  • Developing mechanisms for broad availability and distribution of data.

    • Main Results:

    • The Protein Sequence Database is structured based on biological concepts and sequence homology.
    • PIR-International curates multiple genomic and protein sequence databases.
    • Established mechanisms ensure wide accessibility and distribution of these scientific databases.

    Conclusions:

    • PIR-International plays a crucial role in fostering international cooperation for scientific database development.
    • The Protein Sequence Database and associated resources are vital scientific assets.
    • Accessible and distributed databases facilitate research in protein evolution and genomics.