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Flypub To Study Ethanol Induced Behavioral Disinhibition and Sensitization
Published on: May 18, 2020
Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation
1Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
Abstract:
The effect of 5-HT3 receptor antagonists such as ondansetron, ICS 205-930, MDL 72222, metoclopramide, and zacopride was investigated on the ethanol as well as diazepam withdrawal phenomena in the present study. There was a significant increase in locomotor activity in the ethanol- as well as diazepam-withdrawn rats. The treatment of rats with 5-HT3 receptor antagonists during withdrawal phase did not modify the effect. The ethanol-withdrawn rats were more sensitive to pentylenetetrazole (PTZ)-induced convulsions as compared to control animals. 5-HT3 receptor antagonists did not attenuate the increased sensitivity of ethanol-withdrawn rats to PTZ. These observations indicated that 5-HT3 receptor antagonists are ineffective in attenuating hyperlocomotor activity following abrupt termination of chronic administration of ethanol or diazepam, and increased sensitivity to PTZ in the ethanol-withdrawn rats.
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