[The role of lipid peroxidation processes in the pathogenesis of paraneoplastic anemia]

Growth of Pliss lymphosarcoma inoculated into rats was accompanied by development of amenia, whereas content of Schiff bases was increased and concentration of SH-groups was decreased in erythrocytes of peripheric blood. Alterations in content of lipid peroxidation products, especially the decrease of SH-groups, were detected before manifestations of the anemia indications registered under laboratory conditions. This suggests the importance of lipid peroxidation in elevated rate of erythrocyte hemolysis during tumor growth.