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Related Experiment Videos

Ketoconazole induced papilledema

M Or1, H Akbatur, B Hasanerisoğlu

  • 1Department of Opthalmology, Gazi University Faculty of Medicine, Ankara, Turkey.

Acta Ophthalmologica
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

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High doses of ketoconazole (an antifungal drug) caused bilateral papilledema, a condition of swelling around the optic nerve. Symptoms resolved after discontinuing the medication, marking a potential new side effect.

Area of Science:

  • Pharmacology
  • Ophthalmology
  • Endocrinology

Background:

  • Hirsutism is a condition characterized by excessive hair growth in women.
  • Ketoconazole is a broad-spectrum antifungal agent with known potential side effects.
  • High-dose ketoconazole therapy is sometimes used off-label for conditions like hirsutism.

Observation:

  • A patient with hirsutism was treated with high-dose ketoconazole (800 mg/day) for four months.
  • During treatment, the patient developed bilateral papilledema, indicated by swelling of the optic discs.
  • The papilledema resolved completely after the cessation of ketoconazole therapy.

Findings:

  • This case report documents the first instance of bilateral papilledema associated with ketoconazole use.
  • The temporal relationship between high-dose ketoconazole administration and the onset/resolution of papilledema suggests a causal link.

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  • The exact mechanism by which ketoconazole may induce papilledema remains to be elucidated.

    • Implications:

    • Clinicians should be aware of the potential for ketoconazole to cause papilledema, especially at high doses.
    • Ophthalmological monitoring may be warranted in patients receiving long-term, high-dose ketoconazole therapy.
    • Further research is needed to understand the pathophysiology and incidence of this adverse drug reaction.