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High temperature RF SQUIDs for biomedical applications

Y Zhang¹, Y Tavrin, M Mück

¹Forschungszentrum Jülich, Institut für Schicht- and Ionentechnik (ISI), Germany.

Physiological Measurement

|May 1, 1993

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We developed radio-frequency superconducting quantum interference device (SQUID) magnetometers operating at liquid nitrogen temperatures (77 K). These devices achieve high magnetic field resolution, enabling the detection of biomedical signals like brain activity.

Area of Science:

Applied Physics
Biomedical Engineering
Superconducting Devices

Background:

Superconducting Quantum Interference Devices (SQUIDs) offer high magnetic field sensitivity.
Operating SQUIDs at liquid nitrogen temperatures (77 K) presents a significant technological challenge and opportunity.
Low-frequency magnetic signals are crucial for biomedical diagnostics.

Purpose of the Study:

To investigate the feasibility of radio-frequency (RF) SQUID magnetometers and gradiometers operating at 77 K.
To achieve a magnetic field resolution suitable for biomedical applications.
To demonstrate the capability of these devices in detecting biological signals.

Main Methods:

Fabrication of flux-focusing structures using epitaxial YBa2Cu3O7-chi films.

Related Experiment Videos

Testing of radio-frequency SQUID magnetometers and gradiometers at liquid nitrogen temperature (77 K).

Measurements conducted in a magnetically shielded room and in the absence of shielding.

Main Results:

Achieved magnetic field resolution better than 200 fT Hz-1/2 at frequencies below 1 Hz.
Successfully recorded diagnostically relevant human heart signals and voluntary eye-blink signals at 77 K.
Recorded the first evoked response of a human brain using the developed SQUID magnetometer.
Demonstrated heart signal detection using a first-order gradiometer without magnetic shielding.

Conclusions:

Radio-frequency SQUID magnetometers and gradiometers are feasible for operation at liquid nitrogen temperatures.
The achieved magnetic field resolution is promising for low-frequency biomedical diagnostic applications.
Further improvements in magnetic field resolution by an order of magnitude are anticipated.