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Human monocyte glucose metabolism in lymphoma
The Journal of Laboratory and Clinical Medicine
|February 1, 1977
Summary
Lymphoma activates monocyte glucose metabolism, particularly in males, with glycolysis and hexose monophosphate shunt activity increasing. This effect is less apparent in females due to naturally higher metabolic rates in healthy women.
Area of Science:
- Biochemistry
- Immunology
- Oncology
Background:
- Monocytes play a crucial role in immune responses and can be activated in various conditions, including lymphoma.
- Altered glucose metabolism is a hallmark of activated immune cells.
Purpose of the Study:
- To investigate alterations in monocyte glucose metabolism in lymphoma patients.
- To explore the influence of sex and age on these metabolic changes.
Main Methods:
- Measurement of glycolysis (GU), hexose monophosphate shunt (HMPS) activity, and Krebs cycle activity in monocytes.
- Comparison between 22 untreated lymphoma patients and 32 normal subjects, stratified by sex and age.
Main Results:
- Lymphoma patients exhibited significantly elevated glucose metabolism (GU, HMPS, Krebs cycle) compared to normal subjects, indicating monocyte activation.
- Enhanced glucose metabolism was significant in male lymphoma patients but not in female patients.
- Male patients over and under 40 showed significantly increased HMPS activity, and those over 40 also had increased GU.
- No significant differences were observed in female lymphoma patients compared to controls, attributed to higher baseline HMPS in healthy women.
Conclusions:
- Lymphoma activates monocyte glucose metabolism, with the effect being more pronounced and detectable in males.
- Sex-specific differences in baseline monocyte metabolism can mask lymphoma-associated changes in women.
- Consideration of sex is crucial for accurate evaluation of human monocyte function and metabolism in disease states.