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Effects of rhubarb tannins on renal function in rats with renal failure
T Yokozawa1, K Fujioka, H Oura
1Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Nihon Jinzo Gakkai Shi
|January 1, 1993
Abstract:
The effects of tannins purified from Rhei Rhizoma on various parameters of renal function were investigated in rats with adenine-induced renal failure. The glomerular filtration rate, renal plasma flow and renal blood flow were significantly increased in rats given (-)-epicatechin 3-O-gallate at a dose of 5 or 10 mg/kg body weight/day for 24 days. Administration of 5 mg of procyanidin B-2 3,3'-di-O-gallate also led to a significant increase in renal functional parameters. However, unlike the former two components, procyanidin C-1 3,3',3''-tri-O-gallate caused aggravation of renal function.