Sustained-release applications of montmorillonite interaction with amphetamine sulfate

Area of Science:

• Pharmacology
• Materials Science

Background:

• Montmorillonite is a clay with potential applications in drug delivery.
• Amphetamine sulfate is a stimulant medication with a defined therapeutic range.

Purpose of the Study:

• To investigate the effect of montmorillonite on amphetamine sulfate's urinary recovery.
• To evaluate the pharmacokinetic profile of amphetamine sulfate when formulated with montmorillonite.

Main Methods:

• Urinary recovery studies were conducted.
• A 1:20 drug-montmorillonite complex was prepared and combined with pure amphetamine sulfate in a 1:1 ratio.
• Bioavailability was assessed over 48 hours.

Main Results:

• Montmorillonite significantly influenced the initial urinary therapeutic levels of amphetamine sulfate.
• The drug-montmorillonite complex formulation exhibited recovery profiles similar to prolonged-release dosage forms.
• Comparable bioavailability was observed for the 1:20 complex, pure drug, and combination formulations at 48 hours.

Conclusions:

• Montmorillonite can modify the release characteristics of amphetamine sulfate.
• Formulations involving montmorillonite show potential for achieving prolonged-release profiles.
• Further research into montmorillonite-based drug delivery systems is warranted.