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Hirschsprung's disease: clinical and experimental observations
1Children's Research Centre, Our Lady's Hospital for Sick Children, Crumlin, Dublin, Ireland.
World Journal of Surgery
|May 1, 1993
Summary
Hirschsprung's disease (HD) enterocolitis may stem from infections. This study offers evidence supporting an infectious cause for this serious complication in newborns with HD.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Infectious Diseases
Background:
- Hirschsprung's disease (HD) is a common neonatal intestinal obstruction.
- HD involves the absence of ganglion cells in the distal bowel.
- Enterocolitis is a severe complication of HD with an unclear cause.
Purpose of the Study:
- To investigate the potential infectious etiology of enterocolitis in patients with Hirschsprung's disease.
Main Methods:
- This study analyzed clinical data and microbiological findings in newborns with HD-associated enterocolitis.
- The research focused on identifying infectious agents and their correlation with enterocolitis development.
Main Results:
- The findings suggest a link between specific infections and the onset of enterocolitis in HD patients.
- Evidence supports an infectious trigger for enterocolitis complicating Hirschsprung's disease.
Conclusions:
- An infectious etiology is a plausible cause for enterocolitis in Hirschsprung's disease.
- Further research into infectious triggers could improve management and outcomes for HD patients.