Related Experiment Video
Updated: Jul 24, 2026

Creating Defined Gaseous Environments to Study the Effects of Hypoxia on C. elegans
Published on: July 20, 2012
[Carnosine in adaptation to hypobaric hypoxia]
Abstract:
Adaptation to hypobaric hypoxia causes increases in the carnosine content in rat liver mitochondria. Model experiments showed that carnosine added to isolated rat liver mitochondria increases the rate of ADP-stimulated respiration with alpha-ketoglutarate (but not with succinate) as well as the intensity (ADP/t) and efficiency (ADP/O) of oxidative phosphorylation--by 56%, 49%, and 15%, respectively. Increases in the intensity and efficiency of oxidative phosphorylation (by 100% and 30%, respectively) were also observed in liver mitochondria isolated from rats adapted to hypobaric hypoxia. Activation of ADP-stimulated respiration was found after addition of glutamate plus malate and pyruvate plus glutamate to liver mitochondria. This stimulating effect was coupled to aminotransferase activation and was abolished by the transaminase inhibitor aminooxyacetate. Carnosine addition to mitochondria or its accumulation in mitochondria under hypoxia is associated with activation of alpha-ketoglutarate oxidation and its formation through transamination.
More Related Videos
05:45Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
05:45Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Related Concept Videos
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Oxygen Transport in the Blood
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Chemical Factors Affecting Respiration Centers
CO2 has a potent influence on respiration and is strictly regulated. Under...
Cellular Adaptation II: Hypertrophy