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Piperidineacrylate derivatives as potential antiallergy agents
M Sugiyama1, T Sakamoto, Y Kamigaki
1Medicinal Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|May 1, 1993
Abstract:
A new series of piperidineacrylate derivatives was prepared and evaluated for antiallergic activity. Most of the compounds showed potent activities in the rat passive cutaneous anaphylaxis (PCA) assay. In particular, ethyl 1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidineacrylate (1a) was more potent than oxatomide and terfenadine in this assay, and was selected for further study. Some pharmacological properties of 1a are presented.