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Path analysis and sib-pair linkage
1Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447.
Genetic Epidemiology
|January 1, 1993
Abstract:
When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed.