Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transient bacteremia and endocarditis prophylaxis. A review

E D Everett, J V Hirschmann

    Medicine
    |January 1, 1977
    PubMed
    Summary

    Transient bacteremia, often from dental work, can risk infective endocarditis. Prophylactic antibiotics are recommended for predictable bacteremia in susceptible patients, especially those with prosthetic valves undergoing certain procedures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Charles Edward Smith: Coccidioidomycologist and public health leader.

    Journal of medical biography·2020
    Same author

    The Discovery of Q Fever and Its Cause.

    The American journal of the medical sciences·2019
    Same author

    Paul Beeson (1908-2006), Distinguished Physician.

    Journal of medical biography·2018
    Same author

    From Squirrels to Biological Weapons: The Early History of Tularemia.

    The American journal of the medical sciences·2018
    Same author

    Raynaud's phenomenon-Correction.

    Journal of general internal medicine·2016
    Same author

    When antibiotics are unnecessary.

    Dermatologic clinics·2008

    Area of Science:

    • Medical Microbiology
    • Cardiology
    • Infectious Diseases

    Background:

    • Transient bacteremia, the presence of bacteria in the bloodstream, is common during various medical procedures and daily activities.
    • While often asymptomatic, bacteremia poses a risk for developing infective endocarditis, particularly in susceptible individuals.
    • The exact numerical risk of bacteremia leading to endocarditis remains uncertain.

    Purpose of the Study:

    • To evaluate the necessity and efficacy of prophylactic antibiotics in preventing infective endocarditis.
    • To identify specific procedures and patient populations that would benefit from antibiotic prophylaxis.
    • To provide evidence-based recommendations for antimicrobial use in preventing procedure-related bacteremia and endocarditis.

    Main Methods:

    • Review of existing literature on bacteremia associated with medical and dental procedures.
    • Analysis of experimental evidence, including studies in animal models (rabbits), regarding antibiotic efficacy.
    • Synthesis of data to formulate clinical recommendations for antibiotic prophylaxis.

    Main Results:

    • Antibiotic prophylaxis is suggested for procedures with a high likelihood of causing bacteremia, such as dental manipulations and urinary tract instrumentation.
    • Evidence supports antibiotic use in susceptible patients, though direct human proof for preventing endocarditis is limited.
    • Specific antibiotic regimens are recommended for different procedures and patient groups, including those with prosthetic valves.

    Conclusions:

    • Prophylactic antimicrobials are prudent in situations with predictable bacteremia, particularly for dental procedures and urinary tract instrumentation.
    • Endocarditis-prone patients undergoing abdominal procedures may benefit from prophylaxis until incidence data are clearer.
    • Patients with prosthetic valves should receive antibiotic pretreatment for specific gastrointestinal and interventional procedures.

    Related Experiment Videos