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Antibiotic Selection00:57

Antibiotic Selection

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
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Related Experiment Video

Updated: Jun 28, 2026

Antibiotic Dereplication Using the Antibiotic Resistance Platform
10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

When antibiotics are unnecessary.

J V Hirschmann1

  • 1Medical Service (111), Puget Sound VA Medical Center, 1660 South Columbian Way, Seattle, WA 98108, USA. pepsi@u.washington.edu

Dermatologic Clinics
|November 6, 2008
PubMed
Summary
This summary is machine-generated.

Dermatologists can reduce unnecessary antimicrobial use by avoiding these agents when evidence shows they are ineffective. This includes certain skin conditions and prophylactic use in most surgical and high-risk patient scenarios.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Dermatology
  • Infectious Disease
  • Pharmacology

Background:

  • Antimicrobial resistance is a growing global health concern.
  • Judicious use of antimicrobial agents in dermatology is crucial to combat resistance.
  • Evidence-based guidelines are needed to inform appropriate antimicrobial prescribing practices.

Purpose of the Study:

  • To identify dermatologic conditions and surgical scenarios where antimicrobial agents are ineffective or not indicated.
  • To provide evidence-based recommendations for decreasing unnecessary antimicrobial use in dermatology.
  • To inform dermatologists on appropriate antimicrobial stewardship.

Main Methods:

  • Review of controlled trials and clinical evidence regarding antimicrobial efficacy in dermatologic conditions.
  • Analysis of guidelines for prophylactic antibiotic use in dermatologic surgery and in patients with prosthetic devices or cardiac conditions.
  • Evaluation of topical antibiotic efficacy for wound care.

Main Results:

  • Antimicrobials are ineffective for cutaneous abscesses, inflamed epidermal cysts, uninfected atopic eczema, and uncomplicated diabetic or venous ulcers.
  • Prophylactic antibiotics are rarely indicated for routine dermatologic surgery and generally not for patients with prosthetic joints/grafts.
  • Topical antibiotics offer no benefit over white petrolatum for sutured wounds; moist dressings suffice.

Conclusions:

  • Dermatologists can significantly decrease unnecessary antimicrobial prescribing by adhering to evidence-based indications.
  • Avoiding antimicrobials in specific non-infectious dermatoses and for most prophylactic surgical uses is recommended.
  • Optimizing wound care with non-antibiotic options and appropriate dressing techniques is advised.