[The role of pharmacology in the comprehensive prophylaxis of post-traumatic fat embolism]

Immediate high-standard provisions implemented as soon as possible after serious injuries with the aim to prevent the development of shock or to treat incipient and developing shock is one of the most important aspects of prophylaxis of the syndrome of traumatic fat embolism (FE). An important place is held by the rostoration of normal microcirculation, replacement of blood losses and the control of hypoxia, in particular by artificial pulmonary ventilation. A high caloric intake both by the parenteral and enteral route has among others the objective to prevent excessive development of lipolysis. Surgical operations with the exception of urgent ones which must not be delayed should be postponed till complete regression of clinical manifestations of traumatic shock. The group of comprehensive provisions comprises pharmacological provisions against traumatic shock and pharmacological participation in the prophylaxis of the FE syndrome: Lipostabil; Trasylol; heparin and other anticoagulants in small doses; hydrocortisone; dextrans, CaCl2 and possibly other effective substances or drugs in rational individually recommended doses and expedient combinations.