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[The anti-arrhythmic action of exogenous creatine phosphate and its effect on myocardial electrophysiological
Abstract:
The experiments on rats with overload heart failure have shown that creatine phosphate (CP) used in a single dose at the peak of severe signs of cardiac decompensation was found to produce a short-term normalization of rhythm and an increase in heart rate. With multiple doses, the agent slowed down the development of bradycardia, prevented arrhythmias and promoted the rise of longevity in the experimental animals. At the same time, exogenous CP failed to affect energy-dependent processes of re- and depolarization which were impaired in the myocardium in acute heart failure.
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