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Related Experiment Videos

Are controls in schizophrenia research "normal"?

S C Olson1, R A Bornstein, S B Schwarzkopf

  • 1Department of Psychiatry, Ohio State University.

Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists
|March 1, 1993
PubMed
Summary
This summary is machine-generated.

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Many "normal" research volunteers have personal or family mental health conditions. This psychiatric history, including substance abuse and mood disorders, influences study outcomes and must be considered in research design.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Control groups in psychiatric research are crucial for valid findings.
  • Defining 'normal' in volunteers is challenging due to potential hidden psychopathology.
  • Participant recruitment via advertisement may attract individuals with specific personal or familial mental health histories.

Purpose of the Study:

  • To describe the psychiatric assessment of "normal" volunteers for a psychosis research study.
  • To evaluate the prevalence of personal and family psychopathology in this volunteer cohort.
  • To investigate the relationship between ventricular size and demographic/psychometric variables.

Main Methods:

  • Structured psychiatric interviews and family history (FH-RDC) were administered to volunteers.

Related Experiment Videos

  • Volunteers were screened via phone and in-person interviews.
  • Magnetic resonance imaging (MRI) was used to assess ventricular size.
  • Minnesota Multiphasic Personality Inventory (MMPI) was administered.

    • Main Results:

    • 17.6% of initial volunteers were excluded for major psychopathology.
    • 28.6% of completers had subthreshold mood or substance use disorders.
    • 45% of subjects had a negative family history for mental disorders.
    • Larger ventricular size in males correlated with higher education and MMPI Schizophrenia scale scores.

    Conclusions:

    • "Normal" volunteers often possess personal or familial psychopathology, impacting research validity.
    • The characteristics of control groups need careful consideration in study design and recruitment.
    • Increased sensitivity of neuroimaging necessitates rigorous control group characterization.