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[Severe Amanita phalloides poisoning in a 7-year-old girl]
V Rambousek1, J Janda, M Sikut
1I. dĕtská klinika FN v Motole, Praha.
Ceskoslovenska Pediatrie
|June 1, 1993
Insights
A child experienced severe poisoning with liver damage and coma. Treatment with Silymarin and high-dose penicillin may have contributed to a positive outcome in this critical poisoning case.
Area of Science:
- Toxicology
- Pharmacology
- Hepatology
Background:
- Severe poisoning cases require prompt and effective interventions.
- Liver damage and hepatic coma indicate critical toxicity levels.
- Investigating combined therapeutic approaches is crucial for managing poisoning.
Observation:
- A pediatric case presented with extremely low prothrombin-time (<10% of normal).
- The patient developed severe hepatic coma, signifying advanced liver failure.
- The poisoning severity necessitated aggressive medical management.
Findings:
- The patient received a combination treatment of Silymarin and high-dose G-Penicillin.
- A favorable outcome was observed despite the initial critical condition.
- Silymarin and G-Penicillin combination therapy is hypothesized to be beneficial.
Implications:
- This case highlights a potential therapeutic strategy for severe poisoning.
- Silymarin and penicillin combination may offer protective effects against liver toxicity.
- Further research is warranted to validate the efficacy of this treatment regimen.
Abstract:
Authors describe a case of a very severe poisoning, the prothrombin-time was less than 10% of the normal value and the child developed hepatic coma. We suppose, the favourable outcome may have been influenced by the treatment with Silymarin in combination with high doses of G-Penicillin.