Plane xanthomatosis with chronic lymphatic leukaemia

Area of Science:

• Dermatology
• Hematology
• Oncology

Background:

• Plane xanthomatosis is a rare skin condition characterized by lipid deposits.
• It has been associated with hematological malignancies and monoclonal gammopathies.
• The association between plane xanthomatosis and chronic lymphatic leukemia is not well-documented.

Observation:

• A 67-year-old woman with chronic lymphatic leukemia presented with asymptomatic yellow plaques.
• The lesions were located on the neck, upper arms, and chest.
• Histological examination suggested xanthelasma.

Findings:

• This is the first reported case of plane xanthomatosis in a patient with chronic lymphatic leukemia.
• The findings suggest a potential link between this specific hematological malignancy and the development of xanthomas.
• Histology confirmed the presence of xanthelasma, a common form of xanthoma.

Implications:

• This case expands the known associations of plane xanthomatosis.
• Further research is warranted to investigate the potential pathogenetic mechanisms linking chronic lymphatic leukemia and xanthoma development.
• Clinicians should consider screening for hematological malignancies in patients presenting with plane xanthomatosis.