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[Interaction of midazolam and thiopental in amnestic effect]
K Koyama1, A Katayama, T Yamada
1Department of Anesthesiology, Saitama Medical Center, Saitama Medical School, Kawagoe.
Abstract:
Interaction of midazolam and thiopental in amnestic effect was studied in 30 adult patients who underwent elective surgery of lower extremities under epidural or spinal anesthesia in combination with oxygen, nitrous oxide and low concentration of sevoflurane. Combination of midazolam 2.0-3.0 mg (0.041 +/- 0.006 mg.kg-1) and thiopental 3-5 mg.kg-1 produced amnestic effect in 87% of patients. No side effects, such as decrease in O2 saturation, upper airway obstruction, cardiovascular depression and delayed emergence were observed with this small dose of midazolam. Administration of midazolam 2.0-3.0 mg before epidural, or spinal anesthesia in the operating room under observation of anesthesiologists, followed by thiopental 3-5 mg.kg-1, was safe and comfortable to the patients.
Insights
Midazolam and thiopental combination effectively produced amnesia in 87% of patients undergoing surgery. This combination, using low-dose midazolam, proved safe with no observed side effects.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Anesthesia often requires agents to induce amnesia.
- Midazolam and thiopental are commonly used anesthetic agents.
Purpose of the Study:
- To evaluate the amnestic effect of midazolam and thiopental combination.
- To assess the safety of low-dose midazolam in combination with thiopental.
Main Methods:
- 30 adult patients undergoing lower extremity surgery under epidural/spinal anesthesia.
- Combination of midazolam (2.0-3.0 mg) and thiopental (3-5 mg.kg-1).
- Anesthesia included oxygen, nitrous oxide, and low-concentration sevoflurane.
Main Results:
- 87% of patients experienced an amnestic effect.
- No significant side effects were observed, including O2 desaturation, airway obstruction, or cardiovascular depression.
- Patients reported the administration as safe and comfortable.
Conclusions:
- The combination of midazolam and thiopental is effective for inducing amnesia during surgery.
- Low-dose midazolam in this combination is safe and well-tolerated.
- This anesthetic approach offers a comfortable and safe experience for patients.