[Radiation response and radiation effects in salivary glands (author's transl)]

Using nuclear medical techniques, especially that of functional scintigraphy with the gamma camera after injection of 99mTc-pertechnetate, it is possible to objectify dose-dependent radiation effects on the salivary glands: Radiation doses from 500 to 1200 rd lead to a temporary reduction of the capacity to accumulate the 99mTc-pertechnetate. This functional restriction is reversible. With radiation doses of more than 2000 rd there appear irreversible functional disorders being proportional to dosage. Focal doses of about 6000 rd produce a complete loss of the capacity for 99mTc accumulation of the salivary glands. The chronological course of radiation response is characterized by a) an activation of the radionuclide accumulation following ca. 3000 rd in about three weeks, b) a following decrease of the capacity for accumulation of 99mTc, c) a renewed activation after the end of irradiation, and d)the progressive and irreversible loss of function of the salivary glands.