Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lateral geniculate nucleus in glaucoma

N Chaturvedi1, E T Hedley-Whyte, E B Dreyer

  • 1Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary, Boston 02114.

American Journal of Ophthalmology
|August 15, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying and ranking novel independent features for cardiovascular disease prediction in people with type 2 diabetes.

medRxiv : the preprint server for health sciences·2023
Same author

Gnomonious projections for bend-free textures: thoughts on the splay-twist phase.

Proceedings. Mathematical, physical, and engineering sciences·2020
Same author

Ethnic differences in the severity and clinical management of type 2 diabetes at time of diagnosis: A cohort study in the UK Clinical Practice Research Datalink.

Diabetes research and clinical practice·2020
Same author

Mechanisms to splay-bend nematic phases.

Physical review. E·2019
Same author

Birth weight and cardiac function assessed by echocardiography in adolescence: Avon Longitudinal Study of Parents and Children.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2018
Same author

Performance Analysis of GaN Capping Layer Thickness on GaN/AlGaN/GaN High Electron Mobility Transistors.

Journal of nanoscience and nanotechnology·2018
Same journal

Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

American journal of ophthalmology·2026
Same journal

Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

American journal of ophthalmology·2026
Same journal

Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

American journal of ophthalmology·2026
Same journal

Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

American journal of ophthalmology·2026
Same journal

Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

American journal of ophthalmology·2026
See all related articles

Glaucoma significantly damages the magnocellular (M) pathway of the lateral geniculate nucleus (LGN), a key visual processing center. This study found reduced M-layer cell density in glaucoma patients, indicating selective tissue loss.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cell Biology

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Optic nerve damage in glaucoma affects visual pathway integrity.
  • The lateral geniculate nucleus (LGN) is a critical relay for visual information.

Purpose of the Study:

  • To investigate glaucomatous damage in the LGN, specifically its magnocellular and parvocellular layers.
  • To determine if glaucoma selectively affects specific neuronal populations within the LGN.

Main Methods:

  • Autopsy sections of the LGN from five glaucoma patients and five controls were analyzed.
  • Neuronal cell density was quantified in 40 random microscopic fields per layer.
  • Statistical comparison of cell counts between glaucoma and control groups.

Related Experiment Videos

Main Results:

  • A significant reduction in magnocellular layer cell density was observed in the glaucoma group (2.72 cells/mm²) compared to controls (3.76 cells/mm²).
  • No statistically significant difference in parvocellular layer cell density was found between the groups.
  • These findings suggest selective vulnerability of the magnocellular pathway to glaucomatous damage.

Conclusions:

  • Glaucoma causes significant neuronal loss in the magnocellular layers of the LGN.
  • The parvocellular pathway appears less affected by glaucomatous damage.
  • This selective damage may contribute to specific visual deficits observed in glaucoma patients.