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A protein inhibitor, extracted from Hela cells, which recognises a cell surface protease on preneoplastic cells
F S Steven1, J Johnson, P Eason
1Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Manchester, UK.
Anticancer Research
|July 1, 1993
Abstract:
Hela cells originate from a clone of cervical carcinoma cells. The cytoplasm of Hela cells contains a protein which recognises and inhibits a proteolytic enzyme (guanidino-benzoatase) on the surface of Hela cells. This same protease is present on the surface of abnormal epithelial cells obtained from cervical smears, enabling a rhodamine labelled inhibitor extracted from Hela cells to locate abnormal cervical cells in monolayer spreads.