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Frontal-subcortical circuits and human behavior

J L Cummings1

  • 1Department of Neurology, UCLA School of Medicine.

Archives of Neurology
|August 1, 1993
PubMed
Summary

Frontal-subcortical circuits are key to understanding many human behaviors and disorders. Damage to these circuits can cause specific syndromes like executive dysfunction or apathy.

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Area of Science:

  • Neuroscience
  • Behavioral Neurology
  • Psychiatry

Background:

  • Frontal lobe and subcortical structures are interconnected.
  • Disorders affecting these areas manifest in diverse behavioral symptoms.

Purpose of the Study:

  • To review the role of frontal-subcortical circuits in explaining human behavioral disorders.
  • To demonstrate the utility of this circuit model in clinical contexts.

Main Methods:

  • Systematic review of English literature on patients with frontal lobe or subcortical lesions.
  • Inclusion of case reports and group studies with detailed behavioral or neuropsychological data.
  • Evaluation of studies with compelling evidence of frontal-subcortical circuit involvement.

Main Results:

  • Five segregated circuits connect the frontal lobe and subcortical structures.
  • Lesions in subcortical structures mirror clinical syndromes of frontal lobe injury.
  • Specific syndromes correlate with distinct circuits: executive dysfunction (dorsolateral), disinhibition (orbitofrontal), apathy (anterior cingulate).
  • Frontal-subcortical circuits are implicated in depression, mania, OCD, and movement disorders.

Conclusions:

  • Frontal-subcortical circuits are fundamental to mediating various aspects of human behavior.
  • Understanding these circuits provides a framework for explaining a wide range of behavioral disorders.

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