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Multi drug resistant Salmonella typhi in Ludhiana (Punjab)
1Department of Microbiology, Dayanand Medical College & Hospital, Ludhiana, Punjab.
Abstract:
280 Salmonella typhi strains isolated from suspected cases of enteric fever during the year 1990 were studied for susceptibility to the antimicrobial agents chloramphenicol, ampicillin, cotrimoxazole, gentamycin, kanamycin, amikacin, ciprofloxacin by Kirby Baur disc diffusion method. All were blood culture positive cases. 63 strains (21.9%) were found resistant to chloramphenicol, ampicillin, cotrimoxazole, but sensitive to the amino glycosides and ciprofloxacin. Present study shows the prevalence of multi drug resistant Salmonella typhi in this region of Punjab.
Insights
A 1990 study found 21.9% of Salmonella typhi strains resistant to common antibiotics like chloramphenicol. However, these multi-drug resistant bacteria remained sensitive to newer agents, including ciprofloxacin.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Enteric fever, caused by Salmonella typhi, remains a significant public health concern globally.
- Antimicrobial resistance in Salmonella typhi poses a growing threat to effective treatment strategies.
- Understanding regional resistance patterns is crucial for guiding clinical practice.
Purpose of the Study:
- To investigate the antimicrobial susceptibility patterns of Salmonella typhi strains isolated from enteric fever cases in Punjab during 1990.
- To determine the prevalence of multi-drug resistant Salmonella typhi in the studied population.
Main Methods:
- Isolation and identification of 280 Salmonella typhi strains from blood cultures of suspected enteric fever patients.
- Antimicrobial susceptibility testing using the Kirby-Bauer disc diffusion method.
- Evaluation of resistance to chloramphenicol, ampicillin, cotrimoxazole, gentamycin, kanamycin, amikacin, and ciprofloxacin.
Main Results:
- Out of 280 Salmonella typhi strains, 63 (21.9%) exhibited resistance to chloramphenicol, ampicillin, and cotrimoxazole.
- All resistant strains remained sensitive to aminoglycosides (gentamycin, kanamycin, amikacin) and ciprofloxacin.
- The study identified a significant prevalence of multi-drug resistant Salmonella typhi in Punjab.
Conclusions:
- The findings highlight the emergence of multi-drug resistant Salmonella typhi in Punjab by 1990.
- Aminoglycosides and ciprofloxacin represented effective therapeutic options against the resistant strains.
- Continuous monitoring of antimicrobial resistance patterns is essential for public health interventions.