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Multi drug resistant Salmonella typhi in Bombay
H S Sheorey1, D V Kaundinya, V S Hulyalkar
1Deptt. of Microbiology, Grant Medical College, Bombay.
Indian Journal of Pathology & Microbiology
|January 1, 1993
Summary
The 1990 Dombivali fever outbreak in Bombay was identified as multidrug-resistant typhoid fever. This study highlights a significant rise in Salmonella typhi isolation and resistance, with all strains remaining sensitive to ciprofloxacin.
Area of Science:
- Medical Microbiology
- Infectious Diseases Epidemiology
Background:
- An outbreak, termed 'Dombivali fever,' emerged in Bombay in March 1990.
- This outbreak coincided with a notable increase in multidrug-resistant Salmonella typhi (S. typhi) isolations.
Purpose of the Study:
- To compare the 1990 outbreak data with laboratory records from the preceding two years (1988-1989).
- To analyze the incidence and antimicrobial resistance patterns of Salmonella typhi during the outbreak.
Main Methods:
- Retrospective analysis of laboratory data from Sir J.J. Hospital, Bombay.
- Comparison of S. typhi isolation rates and antimicrobial susceptibility testing results between 1990 and 1988-1989.
Main Results:
- A substantial increase in S. typhi isolation in 1990 (215 isolates) compared to 1988-1989 (62 isolates).
- A high incidence of multidrug resistance (MDR) in enteric fever (EF) cases in 1990 (67.6%) versus 1988 (6.2%) and 1989 (23.3%).
- All S. typhi strains isolated in 1990 demonstrated sensitivity to ciprofloxacin.
Conclusions:
- The 'Dombivali fever' outbreak was confirmed as a significant event of multidrug-resistant typhoid fever.
- The findings underscore the growing challenge of antimicrobial resistance in Salmonella typhi infections.
- Ciprofloxacin emerged as a potentially effective treatment option against the resistant strains observed during this outbreak.