Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tuberculosis symposium: emerging problems and promise

J J Ellner1, A R Hinman, S W Dooley

  • 1Case Western Reserve University School of Medicine, Cleveland, OH 44106-4984.

The Journal of Infectious Diseases
|September 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of premorbid nutritional status on TB severity.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

One step further: improving paediatric TB diagnosis through user-centred research approaches.

IJTLD open·2024
Same author

Sex and age differences in Mycobacterium tuberculosis infection in Brazil.

Epidemiology and infection·2018
Same author

Bacterial and fungal meningitis in patients with cancer.

Neurology·2008
Same author

Financing immunization of adults in the United States.

Clinical pharmacology and therapeutics·2007
Same author

Comparison of intermittent ethambutol with rifampicin-based regimens in HIV-infected adults with PTB, Kampala.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2006
Same journal

NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris.

The Journal of infectious diseases·2026
Same journal

Optimizing the Use of Proviral DNA HIV Drug Resistance Testing: Clinical Applications and Cautions.

The Journal of infectious diseases·2026
Same journal

Monitoring HLA-A2-restricted T cell responses and BCLA-specific serostatus during human latent Toxoplasma gondii infection suggests the implication of CD8+ T cells in parasite containment.

The Journal of infectious diseases·2026
Same journal

Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH).

The Journal of infectious diseases·2026
Same journal

Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection.

The Journal of infectious diseases·2026
Same journal

Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals.

The Journal of infectious diseases·2026
See all related articles

Tuberculosis cases surged between 1985-1991 due to immigration, HIV coinfection, and facility outbreaks. Multidrug-resistant tuberculosis (MDR-TB) also emerged, highlighting urgent needs for new diagnostics, drug supplies, and treatments.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Tuberculosis (TB) incidence increased significantly in the US between 1985 and 1991.
  • This rise was attributed to immigration from high-prevalence countries, HIV coinfection, and outbreaks in congregate settings.
  • Multidrug-resistant tuberculosis (MDR-TB) outbreaks coincided with the overall TB increase.

Purpose of the Study:

  • To analyze the causes and trends of the tuberculosis resurgence.
  • To investigate the emergence and characteristics of multidrug-resistant tuberculosis.
  • To identify challenges and propose solutions for controlling tuberculosis.

Main Methods:

  • Review of clinical and epidemiological data on tuberculosis cases.
  • Analysis of trends in TB incidence and drug resistance patterns.

Related Experiment Videos

  • Assessment of factors contributing to TB transmission, including nosocomial spread.

    • Main Results:

    • An excess of 39,000 tuberculosis cases were observed from 1985-1991.
    • Nosocomial transmission was implicated in multidrug-resistant tuberculosis outbreaks.
    • MDR-TB occurred late in HIV-infected individuals and was treatment-refractory.
    • Drug shortages compounded the challenges of rising incidence and resistance.

    Conclusions:

    • The TB epidemic requires novel diagnostic and rapid sensitivity testing approaches.
    • Ensuring adequate supply of existing antitubercular drugs and developing new ones are critical.
    • Governmental agencies have initiated steps to address the escalating public health challenge.
    • Addressing immigration-related TB, HIV coinfection, and MDR-TB transmission is paramount.