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Peri- and postnatal study (segment III) of recombinant granulocyte-macrophage colony stimulating factors (LBD-005) in
1Toxicology Research Center, Korea Research Institute of Chemical Technology, Daejeon.
Abstract:
A perinatal and postnatal study was carried out in Sprague-Dawley rats subcutaneously injected recombinant Granulocyte-Macrophage Colony Stimulating Factors (LBD-005), the growth of stem cell and the development of the hematopoietic cell, at dose levels of 250, 500 and 1000 micrograms/kg/day for a period from day 17 of gestation to day 21 after delivery. All pregnant dams were allowed to litter naturally, and the postnatal development of the offsprings was observed. The incidences of external, internal and skeletal anomalies were not significantly increased in the F1 and F2 fetuses of any treated groups. Recombinant GM-CSF caused no effects on parturition, lactation, postnatal growth and differentiation, behaviour and reproductive ability of the male and female offsprings.