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Application of microwave heating to the synthesis of [18F]fluoromisonidazole
T J McCarthy1, C S Dence, M J Welch
1Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110.
Abstract:
A modified synthesis of [18F]fluoromisonidazole is reported which makes use of microwave heating to reduce the synthesis time to ca 70 min from EOB. A remote system for column purification, concentration and delivery to an HPLC syringe, which reduces the total absorbed dose to the operator, is also described.