Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Mycobacterium avium complex

C B Inderlied1, C A Kemper, L E Bermudez

  • 1Department of Pathology and Laboratory Medicine, Childrens Hospital, Los Angeles, California 90027.

Clinical Microbiology Reviews
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationships between diet-related changes in the gut microbiome and cognitive flexibility.

Neuroscience·2015
Same author

Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.

Cellular and molecular biology (Noisy-le-Grand, France)·2014
Same author

Imported ornamental fish are colonized with antibiotic-resistant bacteria.

Journal of fish diseases·2013
Same author

Mycobacterium avium ssp. hominissuis biofilm is composed of distinct phenotypes and influenced by the presence of antimicrobials.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2010
Same author

Experimental exposure of zebrafish, Danio rerio (Hamilton), to Mycobacterium marinum and Mycobacterium peregrinum reveals the gastrointestinal tract as the primary route of infection: a potential model for environmental mycobacterial infection.

Journal of fish diseases·2007
Same author

Molecular characterisation of Haemophilus influenzae type a and untypeable strains isolated simultaneously from cerebrospinal fluid and blood: novel use of quantitative real-time PCR based on the cap copy number to determine virulence.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2005
Same journal

Diagnostic challenges in re-emerging rickettsioses: why current tools fall short.

Clinical microbiology reviews·2026
Same journal

Current progress in developing mRNA-lipid nanoparticle vaccines against human bacterial pathogens.

Clinical microbiology reviews·2026
Same journal

The gut microbiome and colorectal cancer.

Clinical microbiology reviews·2026
Same journal

Influence of fungi on epithelial homeostasis and role in inflammatory diseases.

Clinical microbiology reviews·2026
Same journal

Coxsackievirus A6 on the rise: epidemiology, pathogenicity, evolutionary dynamics, and antiviral strategy.

Clinical microbiology reviews·2026
Same journal

Intravesical therapies for catheter-associated urinary tract infections: current approaches and future directions.

Clinical microbiology reviews·2026
See all related articles

Mycobacterium avium complex (MAC) disease is a significant opportunistic infection in AIDS patients, impacting quality of life and survival. Advances in molecular techniques and new therapies offer promise for diagnosis and treatment, even in non-AIDS patients.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Microbiology

Background:

  • Mycobacterium avium complex (MAC) is a significant opportunistic infection in human immunodeficiency virus (HIV)-infected individuals, particularly those with acquired immunodeficiency syndrome (AIDS).
  • While known for decades, MAC's role in AIDS morbidity and mortality has gained consensus recently, driving extensive research.
  • The MAC's complex interaction with the immune system, including virulence factors affecting cellular immunity and cytokine regulation, is a key area of study.

Purpose of the Study:

  • To review the current understanding of Mycobacterium avium complex (MAC) disease in the context of acquired immunodeficiency syndrome (AIDS).
  • To highlight the impact of MAC disease on patient quality of life and survival.
  • To discuss advancements in diagnosis, treatment, and antimicrobial resistance of MAC infections.

Related Experiment Videos

Main Methods:

  • Review of existing literature on MAC disease in AIDS patients.
  • Application of molecular techniques to study MAC epidemiology and antimicrobial resistance genetics.
  • Analysis of immune system interactions and virulence factors of MAC.

Main Results:

  • Disseminated MAC disease significantly reduces quality of life and survival in late-stage AIDS patients with low CD4 counts.
  • Molecular techniques have improved understanding of MAC epidemiology and antimicrobial resistance.
  • New therapeutic strategies for prophylaxis and treatment show promise, potentially benefiting both AIDS and non-AIDS patients.

Conclusions:

  • Disseminated MAC disease is a major contributor to morbidity and mortality in AIDS, necessitating improved diagnostic and therapeutic approaches.
  • Early and rapid laboratory detection of MAC in clinical specimens is crucial for effective treatment.
  • Addressing antimicrobial resistance through combination therapies and standardized susceptibility testing is essential for managing MAC infections.