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Priming stimulation facilitates Hebb-type plasticity in the Schaffer collateral-commissural pathways of the mouse
N B Fedorov1, O A Sergeeva, V G Skrebitsky
1Institute of Brain Research, Russian Academy of Medical Science, Moscow.
Experimental Brain Research
|January 1, 1993
Abstract:
Hebb-type plastic changes of synaptic transmission were analyzed in the Schäffer collateral-commissural pathways (SC) of the mouse hippocampal slice. Low frequency (0.05-0.1 Hz) SC stimulation (S2) was paired with intracellular depolarization (100-200 ms; 2-3 nA) of CA1 pyramidal. Postpairing facilitation of synaptic responses in picrotoxin-free medium occurred only when S2 was "primed" with neurons the preceding shock (S1) administered through the same electrode 200 ms before S2. Priming-determined disinhibition in local circuitry is supposed to be responsible for this phenomenon.