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Tetrafibricin, a novel fibrinogen receptor antagonist. II. Structural elucidation
T Kamiyama1, Y Itezono, T Umino
1Nippon Roche Research Center, Kanagawa, Japan.
The Journal of Antibiotics
|July 1, 1993
Abstract:
The structure of tetrafibricin, a novel and potent fibrinogen receptor antagonist isolated from the culture broth of Streptomyces neyagawaensis NR0577, was determined. Tetrafibricin has a unique structure containing primary amine, conjugated tetraenoic acid, and polyhydroxy functionalities that is biosynthetically related to the polyene macrolide antibiotics.