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Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic
K Shindo1, M Kamishohara, A Odagawa
1Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
The Journal of Antibiotics
|July 1, 1993
Abstract:
A new antitumor antibiotic vicenistatin was isolated from the culture broth of Streptomyces sp. HC34. The structure of vicenistatin was elucidated by NMR spectral analysis. Vicenistatin exhibited antitumor activity against human colon carcinoma Co-3 in the xenograft model.