Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Performance of implanted biogalvanic pacemakers

J K Cywinski, A W Hahn, M F Nichols

    Pacing and Clinical Electrophysiology : PACE
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mpox Vaccine Hesitancy Among Sexually Active People with HIV in Care at Risk for mpox.

    AIDS and behavior·2026
    Same author

    A multicenter randomized phase II trial of lenvatinib plus everolimus versus cabozantinib in patients with metastatic clear-cell RCC that progressed on PD-1 immune checkpoint inhibition (LenCabo).

    Annals of oncology : official journal of the European Society for Medical Oncology·2025
    Same author

    Differences in Methamphetamine Use, Self-Reported Impact, and HIV-Related Outcomes by Gender and Sexual Orientation in a Multisite U.S. Cohort of People with HIV in Care.

    AIDS and behavior·2025
    Same author

    Cannabis use patterns among people with HIV before and after legalization.

    Drug and alcohol dependence reports·2024
    Same author

    Alcohol and drug use severity are independently associated with antiretroviral adherence in the current treatment era.

    AIDS care·2023
    Same author

    Blood- and tissue-based tumor genomics: a battle royale or match made in heaven?

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same journal

    Dual Coronary Sinus Lead Strategy to Avoid Tricuspid Valve Traversal in Biventricular Pacing.

    Pacing and clinical electrophysiology : PACE·2026
    Same journal

    A Case of Permanent Pacemaker Implantation via the Epicardial Approach Using the 3830 Lead in an 11-Day-Old Neonate (With Follow-Up of the Above Case).

    Pacing and clinical electrophysiology : PACE·2026
    Same journal

    Cryoballoon Versus Radiofrequency Ablation for Persistent Atrial Fibrillation: Meta-Analysis of Randomized Trials.

    Pacing and clinical electrophysiology : PACE·2026
    Same journal

    Tilt Test Duration in Suspected Vasovagal Syncope: Temporal Patterns and Diagnostic Yield in Patients From Central China.

    Pacing and clinical electrophysiology : PACE·2026
    Same journal

    Combined Leadless Pacing and Subcutaneous ICD Therapy in Long QT Syndromes.

    Pacing and clinical electrophysiology : PACE·2026
    Same journal

    Association of Anesthesia Modality With Procedural Parameters and Clinical Outcomes in PVI for Atrial Fibrillation.

    Pacing and clinical electrophysiology : PACE·2026
    See all related articles

    Hybrid biogalvanic cells show promise for long-term cardiac pacemaker power. These novel power sources demonstrated encouraging electrical performance and minimal local reaction in canine implants, suggesting a 50-year operational lifespan.

    Area of Science:

    • Biomedical Engineering
    • Implantable Medical Devices
    • Biomaterials

    Background:

    • Conventional pacemakers require battery replacements, necessitating surgical procedures.
    • Developing long-lasting, implantable power sources is crucial for improving patient outcomes.
    • Hybrid biogalvanic cells offer a potential solution for extended pacemaker longevity.

    Purpose of the Study:

    • To evaluate the long-term clinical effects and electrical performance of hybrid biogalvanic cells powering cardiac pacemakers in vivo.
    • To assess the biocompatibility and local tissue response to these novel power sources.
    • To determine the potential of biogalvanic cells to achieve a 50-year operational lifespan for pacemakers.

    Main Methods:

    • Seventeen unipolar cardiac pacemakers, powered by hybrid biogalvanic cells, were implanted in canine subjects.

    Related Experiment Videos

  • Long-term clinical observations and electrical performance monitoring of the implanted generators were conducted.
  • Histopathological analysis was performed to evaluate local tissue reactions at the implant sites.

    • Main Results:

    • No systemic pathological changes attributable to the generator or biogalvanic cell were observed in the canine subjects.
    • Local tissue reactions to the implants were mild and comparable to those seen with conventional pacemaker implantations.
    • Biogalvanic cells achieved final steady-state voltage levels of 0.65V to 0.75V within 100-150 days post-implantation.
    • Stable voltage output was maintained for over 36 months in tested units, indicating promising long-term electrical performance.

    Conclusions:

    • Hybrid biogalvanic cells are a safe and effective power source for cardiac pacemakers, demonstrating excellent biocompatibility.
    • The electrical performance of these cells is highly encouraging, supporting their potential for achieving a 50-year operational lifespan.
    • Biogalvanic cell technology represents a significant advancement in developing next-generation, long-duration implantable medical devices.