Related Experiment Videos
Endogenous creatinine clearance in the rat: strain variation
J B Van Liew1, M J Zamlauski-Tucker, L G Feld
1Department of Medicine, University at Buffalo, Children's Hospital of Buffalo, New York 14215.
Life Sciences
|January 1, 1993
Summary
Endogenous creatinine clearance accurately reflects glomerular filtration rate in most rat strains. However, validation with inulin clearance is crucial, especially in diabetic rats or under specific conditions like fasting.
Area of Science:
- Nephrology
- Physiology
- Pharmacology
Background:
- Glomerular filtration rate (GFR) is a key indicator of kidney function.
- Endogenous creatinine clearance is a commonly used, convenient method for estimating GFR.
- Inulin clearance is considered the gold standard for GFR measurement.
Purpose of the Study:
- To evaluate the accuracy of endogenous creatinine clearance in reflecting GFR across different rat strains.
- To assess the influence of various measurement conditions on creatinine clearance accuracy.
- To determine the reliability of creatinine clearance as a surrogate for inulin clearance.
Main Methods:
- Creatinine clearance was measured and compared with inulin clearance in five rat strains.
- Measurement conditions were varied, including anesthesia, urine collection duration, feeding status, and injection technique.
- Statistical analysis was performed to compare clearance values under different conditions.
Main Results:
- Creatinine clearance accurately estimated GFR in Wistar, Wistar-Kyoto, and Spontaneously Hypertensive Rats.
- In Biobreeding/Worcester diabetic-prone and resistant rats, creatinine clearance was consistently lower than inulin clearance.
- Fasting conditions and overnight urine collection reduced creatinine clearance values compared to fed states.
Conclusions:
- Endogenous creatinine clearance is a reliable GFR marker in specific rat strains but requires validation.
- Diabetic rat models and certain measurement conditions necessitate simultaneous inulin clearance comparison.
- Creatinine clearance offers a practical approach for frequent GFR assessments when validated.