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[Azidothymidine in the management of immune deficiency complex]
1Szent-Györgyi Albert Orvostudományi Egyetem Ideg- és Elmegyógyászati Klinikájának Klinikai Farmakológiai Laboratóriuma, Szeged.
The nucleoside-analogue azidothymidine is the first effective drug in the management of HIV-infection although it is not a causal therapy. Azidothymidine increases the life-span of the HIV-positive patients, decreases the incidence of opportunistic infections and enhances the quality of life. The current recommendations is to use the drug at a dose of 500 mg daily in persons with CD4+ counts of less than 500. The (unwanted) side-effects are less prominent at this lower dose. Although there is a very significant research work all over the world for newer drugs for HIV-therapy, it seems that for the foreseeable future azidothymidine will remain the cornerstone of antiretroviral therapy.
The nucleoside-analogue azidothymidine is the first effective drug in the management of HIV-infection although it is not a causal therapy. Azidothymidine increases the life-span of the HIV-positive patients, decreases the incidence of opportunistic infections and enhances the quality of life. The current recommendations is to use the drug at a dose of 500 mg daily in persons with CD4+ counts of less than 500. The (unwanted) side-effects are less prominent at this lower dose. Although there is a very significant research work all over the world for newer drugs for HIV-therapy, it seems that for the foreseeable future azidothymidine will remain the cornerstone of antiretroviral therapy.