[Molecular basis of capacitation and acrosomal reaction]

There has been described molecular events towards preparation of spermatozoa for fertilization as capacitation (process known to be characterized by increased mobility of membrane components on sperm surface) and acrosomal reaction (fusion of spermatozoon plasmalemma with outer acrosomal membrane with following destruction of acrosomal compartment and enzyme release). There have been also described hypotheses concerning activity of exposed during acrosomal reaction receptors for gamete binding and especially sperm receptors located on egg's zona pellucida. The role of acrosomal enzymes in penetration of zona pellucida by sperm as well as inhibition of enzymatic action were discussed in aspect of contraceptive potential.