Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Postmenopausal hot flushes and their management

P Lomax¹, E Schönbaum

¹Department of Pharmacology, School of Medicine, University of California, Los Angeles 90024.

Pharmacology & Therapeutics

|February 1, 1993

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The amount of free corticosterone is increased during lipopolysaccharide-induced fever.

Life sciences·2000

Same author

The effects of drugs on thermoregulation during exposure to hot environments.

Progress in brain research·1998

Same author

(Is there) a pharmacology of thermoregulation?

Annals of the New York Academy of Sciences·1997

Same author

Sudomotor function in human poikilothermia.

Neurology·1995

Same author

Corticosterone modulates interleukin-evoked fever in the rat.

Neuroendocrinology·1994

Same author

Cocaine and body temperature: effect of exercise at high ambient temperature.

Pharmacology·1993

Same journal

Nipocalimab and other FcRn blockers in neuromuscular disorders.

Pharmacology & therapeutics·2026

Same journal

C26:0-lysophosphatidylcholine in X-linked adrenoleukodystrophy.

Pharmacology & therapeutics·2026

Same journal

The CircRNA/miRNA axis in breast cancer: From molecular mechanisms to clinical translation.

Pharmacology & therapeutics·2026

Same journal

Glymphatic-meningeal lymphatic dysfunction in epilepsy: novel mechanistic insights and therapeutic avenues.

Pharmacology & therapeutics·2026

Same journal

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026

Same journal

A-type potassium channels in pain signaling: Fundamental mechanisms and pathophysiological roles.

Pharmacology & therapeutics·2026

See all related articles

Hot flushes, often debilitating, stem from complex physiological and neuroendocrine changes. Understanding these mechanisms is key to developing effective, individualized therapies for managing this common menopausal symptom.

Area of Science:

Reproductive Endocrinology
Thermoregulation Physiology
Neuroendocrinology

Background:

Hot flushes are a common and often debilitating symptom of menopause.
Severe vasomotor disturbances associated with hot flushes can significantly impair daily life.
Current understanding of the pathophysiology of hot flushes necessitates a review for improved therapeutic approaches.

Purpose of the Study:

To elucidate the pathophysiology of hot flushes.
To provide a basis for rationale, individualized patient therapy.
To review current therapeutic strategies for managing hot flushes.

Main Methods:

Review of physiological mechanisms controlling body temperature.
Detailed examination of system changes precipitating menopausal hot flushes.

Related Experiment Videos

Consideration of neuroendocrine events leading to the flushing syndrome.

Main Results:

Discussion of the physiological basis of thermoregulation.
Identification of specific changes triggering menopausal hot flushes.
Analysis of neuroendocrine pathways involved in the flushing syndrome.

Conclusions:

Understanding the pathophysiology of hot flushes is crucial for effective management.
Individualized therapy based on pathophysiological understanding can improve patient outcomes.
A comprehensive review of pathophysiology and therapeutics is presented to guide clinical practice.