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Antigen presentation, loss of immunological memory and AIDS
M R Helbert1, J L'age-Stehr, N A Mitchison
1Robert Koch Institut des Bundesgesundheitsamtes, Berlin, Germany.
Immunology Today
|July 1, 1993
Abstract:
A key factor causing immunodeficiency in HIV infection seems to be defective antigen presentation. Consequently, CD4+ T-cell populations, initially those expressing CD45RO, decrease in number not because of their destruction, but because they fail to expand in response to antigenic stimulation. This view implies that it would be mistaken to aim therapies only at correcting T-cell function or preventing infection of T cells.